A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
Study Purpose
Hidradenitis suppurativa (HS) is an inflammatory skin disease that causes painful lesions in the axilla (underarm), inguinal (groin) and anogenital (anal/genital) regions. This study will assess how safe and effective upadacitinib is in treating adult and adolescent participants with moderate to severe HS who have failed to respond to or are intolerant of anti-tumor necrosis factor (TNF) therapy. Adverse events and change in disease activity will be assessed. Upadacitinib is an approved drug for ulcerative colitis, atopic dermatitis, rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis and is being developed for the treatment of HS. This study is "double-blinded", meaning that neither the trial participants nor the study doctors will know who will be given upadacitinib and who will be given placebo. This study is comprised of 3 periods. In Period 1, participants are randomized into 2 groups called treatment arms where each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to placebo. In Period 2, participants are placed into 6 different groups depending on their placement and results in Period 1. Period 3 is the long-term extension period where participants will continue treatment from Period 2. Approximately 1328 adult and adolescent participants diagnosed with HS will be enrolled in approximately 275 sites worldwide. Participants will receive oral tablets of upadacitinib or placebo once daily for 36 weeks in Period 1 and Period 2. Eligible participants from Period 1 and Period 2 will enter Period 3 and receive oral tablets of upadacitinib or placebo once daily for 68 weeks. Participants will be followed up for approximately 30 days. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular outpatient visits during the study. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires.
Recruitment Criteria
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 12 Years and Over |
Gender | All |
Inclusion Criteria:
- - Diagnosis of HS for at least 6 months prior to Baseline, as determined by the investigator (i.e., through medical history and interview of subject).
- - Documented history of previous use of ≥ 1 TNF inhibitor for HS for at least 12 weeks and/or 1 approved non-anti-TNF biologic therapy for HS for at least 16 weeks characterized by inadequate response or for any duration characterized by intolerance as determined by the investigator.
- - Participant must have a total AN count of ≥ 5 at Baseline.
- - HS lesions must be present in at least 2 distinct anatomic areas at Baseline.
- - At least 1 anatomic area of HS involvement characterized as Hurley Stage II or higher at Baseline.
- - Draining fistula count of ≤ 20 at Baseline.
Exclusion Criteria:
- - History of active skin disease other than HS that could interfere with the assessment of HS, including skin infections (bacterial, fungal, or viral) requiring systemic treatment within 4 weeks of the Baseline visit.
- - Treatment with any investigational drug of chemical or biologic nature within a minimum of 30 days or 5 half-lives (whichever is longer) prior to the first dose of study drug or be currently enrolled in another interventional clinical study.
- - Previous treatment with any cell-depleting therapies including but not limited to anti-CD20 (e.g., rituximab) within 12 months prior to Baseline or until B cell count returns to normal level or pre-treatment level.
- - Use of prescription topical therapies (including topical antibiotics) that can also be used to treat HS within 14 days prior to the Baseline visit.
- - Received any systemic (including oral) antibiotic treatment for HS or any other chronic inflammatory disorder within 14 days prior to the Baseline visit.
Trial Details
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT05889182 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
AbbVie |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
ABBVIE INC. |
Principal Investigator Affiliation | AbbVie |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Chile, Croatia, Czechia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Italy, Japan, Korea, Republic of, Lithuania, Netherlands, New Zealand, Portugal, Puerto Rico, Saudi Arabia, Singapore, Slovakia, Spain, Sweden, Switzerland, Taiwan, Turkey, United Kingdom, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Hidradenitis Suppurativa |
Study Website: | View Trial Website |
Arms
Experimental: Period 1: Upadacitinib Dose A
Participants will receive Upadicitinib Dose A once daily for 16 weeks.
Placebo Comparator: Period 1: Placebo
Participants will receive Placebo once daily for 16 weeks.
Experimental: Period 2: Group 1 - Upadacitinib Dose A
Participants who were randomized to placebo in Period 1 who did not achieve HiSCR 50 (clinical non-responder, CNR) at Week 16 will receive Upadacitinib Dose A once daily for 20 weeks.
Placebo Comparator: Period 2: Group 2 - Placebo
Participants who were randomized to placebo in Period 1 who achieve HiSCR 50 (clinical responder, CR) at Week 16 will continue to receive placebo once daily for 20 weeks.
Experimental: Period 2: Group 3 - Upadacitinib Dose A
Participants who were randomized to upadacitinib Dose A in Period 1 who did not achieve HiSCR 50 (CNR) at Week 16 will continue to receive upadacitinib Dose A once daily for 20 weeks.
Experimental: Period 2: Group 4 - Upadacitinib Dose A
Participants who were randomized to upadacitinib Dose A in Period 1 who achieve HiSCR 50 (CR) at Week 16 will receive upadacitinib Dose A once daily for 20 weeks.
Experimental: Period 2: Group 5 - Upadacitinib Dose B
Participants who were randomized to upadacitinib Dose A in Period 1 who achieve HiSCR 50 (CR) at Week 16 will receive upadacitinib Dose B once daily for 20 weeks.
Experimental: Period 2: Group 6 - Placebo
Participants who were randomized to upadacitinib Dose A in Period 1 who achieve HiSCR 50 (CR) at Week 16 will receive placebo once daily for 20 weeks.
Experimental: Period 3: Long-Term Extension
Eligible participants will continue to receive upadacitinib or placebo for 68 weeks. Participants will be followed-up for approximately 30 days.
Interventions
Drug: - Upadacitinib
Oral Tablets
Drug: - Placebo
Oral Tablets
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Cahaba Dermatology & Skin Health Center /ID# 254876
Birmingham, Alabama, 35244
Status
Recruiting
Address
Medical Dermatology Specialists /ID# 254226
Phoenix, Arizona, 85006
Status
Recruiting
Address
Banner University Medicine Dermatology /ID# 255853
Tucson, Arizona, 85718-1407
Status
Recruiting
Address
Clinical Trials Institute - Northwest Arkansas /ID# 254924
Fayetteville, Arkansas, 72703
Status
Recruiting
Address
Burke Pharmaceutical Research /ID# 254238
Hot Springs, Arkansas, 71913-6404
Status
Recruiting
Address
Arkansas Research Trials /ID# 254233
North Little Rock, Arkansas, 72217
Status
Recruiting
Address
NW Arkansas Clinical Trials Center /ID# 254311
Rogers, Arkansas, 72758
Status
Recruiting
Address
Private Practice - Dr. Joseph Raoof /ID# 254374
Encino, California, 91436
Status
Recruiting
Address
Dermatology Research Associates /ID# 254846
Los Angeles, California, 90045
Status
Recruiting
Address
Integrative Skin Science and Research /ID# 254930
Sacramento, California, 95815
Status
Recruiting
Address
UC Davis Health /ID# 254229
Sacramento, California, 95816-3300
Status
Recruiting
Address
Medderm Associates /ID# 253800
San Diego, California, 92103
Status
Recruiting
Address
Clinical Trials Research Institute /ID# 254466
Thousand Oaks, California, 91320-2130
Status
Recruiting
Address
UConn Health Main /ID# 254507
Farmington, Connecticut, 06032
Status
Recruiting
Address
Yale University School of Medicine /ID# 254586
New Haven, Connecticut, 06510
Status
Recruiting
Address
Skin Care Research Boca Raton /ID# 253814
Boca Raton, Florida, 33486-2269
Status
Recruiting
Address
Apex Clinical Trials /ID# 255756
Brandon, Florida, 33511
Status
Recruiting
Address
Florida Academic Dermatology Center /ID# 254011
Coral Gables, Florida, 33134-5755
Status
Recruiting
Address
Skin Care Research - Hollywood /ID# 254508
Hollywood, Florida, 33021-6748
Status
Recruiting
Address
Life Clinical Trials - Margate - FL-7 /ID# 258613
Margate, Florida, 33063
Status
Recruiting
Address
Skin Care Research - Tampa /ID# 256440
Tampa, Florida, 33607-6438
Status
Recruiting
Address
Advanced Clinical Research Institute /ID# 253746
Tampa, Florida, 33607
Status
Recruiting
Address
Avita Clinical Research /ID# 254471
Tampa, Florida, 33613-1825
Status
Recruiting
Address
Centricity Research /ID# 255470
Columbus, Georgia, 31904-2954
Status
Recruiting
Address
Treasure Valley Medical Research /ID# 255208
Boise, Idaho, 83706
Status
Recruiting
Address
Northwestern University Feinberg School of Medicine /ID# 254503
Chicago, Illinois, 60611-2927
Status
Recruiting
Address
DeNova Research /ID# 254372
Chicago, Illinois, 60611
Status
Recruiting
Address
Northshore University Health System Dermatology Clinical Trials Unit /ID# 254389
Skokie, Illinois, 60077
Status
Recruiting
Address
Dawes Fretzin, LLC /ID# 254390
Indianapolis, Indiana, 46256
Status
Recruiting
Address
Options Research Group /ID# 254537
West Lafayette, Indiana, 47906
Status
Recruiting
Address
U.S. Dermatology Partners Leawood /ID# 255838
Leawood, Kansas, 66211-1453
Status
Recruiting
Address
Beth Israel Deaconess Medical Center /ID# 253811
Boston, Massachusetts, 02215-5400
Status
Recruiting
Address
Beacon Clinical Research, LLC /ID# 254419
Quincy, Massachusetts, 02169
Status
Recruiting
Address
Michigan Dermatology Institute /ID# 254468
Waterford, Michigan, 48328
Status
Recruiting
Address
Dermatology and Skin Center of Lees Summit /ID# 257546
Lee's Summit, Missouri, 64064-2301
Status
Recruiting
Address
MediSearch Clinical Trials /ID# 254392
Saint Joseph, Missouri, 64506
Status
Recruiting
Address
Washington University School of Medicine - St. Louis /ID# 254506
Saint Louis, Missouri, 63130
Status
Recruiting
Address
Vivida Dermatology- Flamingo /ID# 254227
Las Vegas, Nevada, 89119-5190
Status
Recruiting
Address
Skin Cancer and Dermatology Institute - Reno /ID# 254410
Reno, Nevada, 89509
Status
Recruiting
Address
Schweiger Dermatology, P.C. /ID# 254232
Verona, New Jersey, 07044-2946
Status
Recruiting
Address
NorthWell Health - Dermatology /ID# 254704
New Hyde Park, New York, 11042-2058
Status
Recruiting
Address
Onsite Clinical Solutions /ID# 254854
Charlotte, North Carolina, 28277-3816
Status
Recruiting
Address
ClinOhio Research Services /ID# 254851
Columbus, Ohio, 43213-4440
Status
Recruiting
Address
Dermatologists of Southwest Ohio, Inc /ID# 254297
Mason, Ohio, 45040-4520
Status
Recruiting
Address
Lynn Institute of Oklahoma City /ID# 253791
Oklahoma City, Oklahoma, 73112
Status
Recruiting
Address
Paddington Testing Co., Inc. /ID# 254394
Philadelphia, Pennsylvania, 19103
Status
Recruiting
Address
Clinical Research of Philadelphia, LLC /ID# 255308
Philadelphia, Pennsylvania, 19114
Status
Recruiting
Address
Dermatology Associates of Knoxville /ID# 261082
Knoxville, Tennessee, 37917
Status
Recruiting
Address
Arlington Research Center, Inc /ID# 253805
Arlington, Texas, 76011
Status
Recruiting
Address
Bellaire Dermatology Associates /ID# 253797
Bellaire, Texas, 77401
Status
Recruiting
Address
Dermatology Treatment and Research Center /ID# 253795
Dallas, Texas, 75230
Status
Recruiting
Address
Modern Research Associates, PLLC /ID# 253810
Dallas, Texas, 75231
Status
Recruiting
Address
HRMD Research Dallas /ID# 255256
Dallas, Texas, 75240-6246
Status
Recruiting
Address
Dallas Fort Worth Clinical Research Associates (DFWCRA) /ID# 256438
Grapevine, Texas, 76051-3580
Status
Recruiting
Address
Suzanne Bruce and Associates-Houston /ID# 254228
Houston, Texas, 77056
Status
Recruiting
Address
Texas Dermatology Research Center, LLC /ID# 254928
Plano, Texas, 75025
Status
Recruiting
Address
Center for Clinical Studies Webster TX /ID# 254242
Webster, Texas, 77598
Status
Recruiting
Address
University of Utah /ID# 254452
Murray, Utah, 84107
Status
Recruiting
Address
University of Virginia - Dermatology /ID# 254535
Charlottesville, Virginia, 22903
Status
Recruiting
Address
The Education & Research Foundation, Inc. /ID# 254852
Lynchburg, Virginia, 24501-1403
Status
Recruiting
Address
Virginia Clinical Research, Inc. /ID# 254538
Norfolk, Virginia, 23502
Status
Recruiting
Address
North Sound Dermatology /ID# 254554
Mill Creek, Washington, 98012
Status
Recruiting
Address
Premier Clinical Research /ID# 254847
Spokane, Washington, 99202
International Sites
Status
Recruiting
Address
Paratus Clinical Research Woden /ID# 254670
Phillip, Australian Capital Territory, 2606
Status
Recruiting
Address
Holdsworth House Medical Practice /ID# 254411
Darlinghurst, New South Wales, 2010
Status
Recruiting
Address
Skin Health Institute Inc /ID# 254416
Carlton, Victoria, 3053
Status
Recruiting
Address
Sinclair Dermatology - Melbourne /ID# 254412
East Melbourne, Victoria, 3002
Status
Recruiting
Address
Alfred Hospital /ID# 254414
Melbourne, Victoria, 3004
Status
Recruiting
Address
Ordensklinikum Linz GmbH Elisabethinen /ID# 253458
Linz, Oberoesterreich, 4010
Status
Recruiting
Address
Medizinische Universitaet Graz /ID# 253448
Graz, Steiermark, 8010
Status
Recruiting
Address
Medizinische Universitaet Wien /ID# 254096
Vienna, Wien, 1090
Status
Recruiting
Address
Universite Libre de Bruxelles - Hopital Erasme /ID# 254082
Anderlecht, Bruxelles-Capitale, 1070
Status
Recruiting
Address
Grand Hopital de Charleroi /ID# 254091
Charleroi, Hainaut, 6000
Status
Recruiting
Address
UZ Gent /ID# 254090
Gent, Oost-Vlaanderen, 9000
Status
Recruiting
Address
Universitair Ziekenhuis Leuven /ID# 254089
Leuven, Vlaams-Brabant, 3000
Status
Recruiting
Address
Hospital Moinhos de Vento /ID# 254366
Porto Alegre, Rio Grande Do Sul, 90035-001
Status
Recruiting
Address
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 254367
Ribeirão Preto, Sao Paulo, 14049-900
Status
Recruiting
Address
Centro de Desenvolvimento em Estudos Clínicos Brasil - CDEC /ID# 254368
São Paulo, Sao Paulo, 04020-060
Status
Recruiting
Address
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 254370
Sao Paulo, , 05403-000
Status
Recruiting
Address
Acibadem City Clinic Tokuda University Hospital EAD /ID# 253331
Sofia, , 1407
Status
Recruiting
Address
Ambulatory for Specialized Medical Care for skin and venereal diseases /ID# 253329
Sofia, , 1407
Status
Recruiting
Address
Diagnostic consultative center Focus-5 /ID# 253327
Sofiya, , 1463
Status
Recruiting
Address
UMHAT Professor Stoyan Kirkovich /ID# 253328
Stara Zagora, , 6000
Status
Recruiting
Address
Dermatology Research Institute - Blackfoot Trail /ID# 261413
Calgary, Alberta, T2J 7E1
Status
Recruiting
Address
Beacon Dermatology Inc /ID# 254564
Calgary, Alberta, T3A 2N1
Status
Recruiting
Address
Rejuvenation Dermatology - Edmonton Downtown /ID# 254715
Edmonton, Alberta, T5J 3S9
Status
Recruiting
Address
Dr. Chih-ho Hong Medical Inc. /ID# 254378
Surrey, British Columbia, V3R 6A7
Status
Recruiting
Address
Enverus Medical Research /ID# 254380
Surrey, British Columbia, V3V 0C6
Status
Recruiting
Address
Wiseman Dermatology Research /ID# 254117
Winnipeg, Manitoba, R3M 3Z4
Status
Recruiting
Address
Karma Clinical Trials /ID# 254120
St. John's, Newfoundland and Labrador, A1A 4Y3
Status
Recruiting
Address
LEADER Research /ID# 254379
Hamilton, Ontario, L8L 3C3
Status
Recruiting
Address
DermEffects /ID# 254116
London, Ontario, N6H 5L5
Status
Recruiting
Address
Lynde Institute for Dermatology /ID# 254713
Markham, Ontario, L3P 1X2
Status
Recruiting
Address
SKDS Research /ID# 254714
Newmarket, Ontario, L3Y 5G8
Status
Recruiting
Address
York Dermatology Clinic and Research Centre /ID# 254115
Richmond Hill, Ontario, L4C 9M7
Status
Recruiting
Address
Research Toronto /ID# 255273
Toronto, Ontario, M4W 2N4
Status
Recruiting
Address
Diex Recherche Québec Inc. /ID# 254381
Québec, Quebec, G1V 4T3
Status
Recruiting
Address
Dre Angelique Gagne-Henley M.D. inc. /ID# 255632
Saint-Jerome, Quebec, J7Z 7E2
Status
Recruiting
Address
SkinSense Dermatology /ID# 254119
Saskatoon, Saskatchewan, S7K 0H6
Status
Recruiting
Address
Fundacion Innovacion Cardiovascular /ID# 254561
Independencia, Region Metropolitana De Santiago, 8380465
Status
Recruiting
Address
Sociedad Icalma Spa /Id# 254560
Las Condes, , 7580206
Status
Recruiting
Address
Clinica Dermacross /ID# 254558
Santiago, , 7640881
Status
Recruiting
Address
Centro Internacional de Estudios Clinicos - CIEC /ID# 254559
Santiago, , 8420383
Status
Recruiting
Address
DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 253587
Zagreb, Grad Zagreb, 10000
Status
Recruiting
Address
Klinicki bolnicki centar Zagreb /ID# 253786
Zagreb, Grad Zagreb, 10000
Status
Recruiting
Address
Klinika za djecje bolesti Zagreb /ID# 253588
Zagreb, Grad Zagreb, 10000
Status
Recruiting
Address
Klinicki Bolnicki Centar (KBC) Split /ID# 253789
Split, Splitsko-dalmatinska Zupanija, 21000
Status
Recruiting
Address
Naftalan - Specijalna bolnica za medicinsku rehabilitaciju /ID# 253586
Ivanic-Grad, Zagrebacka Zupanija, 10310
Status
Recruiting
Address
Poliklinika Solmed /ID# 254732
Grad Zagreb, , 10000
Status
Recruiting
Address
Specialty hospital Medico /ID# 254731
Rijeka, , 51000
Status
Recruiting
Address
Karlovarska Krajska Nemocnice - Karlovy Vary /ID# 253456
Karlovy Vary, , 360 01
Status
Recruiting
Address
Duplicate_Fakultni Nemocnice v Motole /ID# 253455
Prague, , 150 00
Status
Recruiting
Address
Fakultni nemocnice Kralovske Vinohrady /ID# 253454
Praha, , 100 34
Status
Recruiting
Address
Oulun yliopistollinen sairaala /ID# 253969
Oulu, , 90220
Status
Recruiting
Address
Terveystalo Tampere /ID# 253968
Tampere, , 33100
Status
Recruiting
Address
Chu de Nice-Hopital Larchet Ii /Id# 253504
Nice, Alpes-Maritimes, 06200
Status
Recruiting
Address
Centre Hospitalier Universitaire de Bordeaux - Groupe Hospitalier Saint-Andre /ID# 254139
Bordeaux, Gironde, 33000
Status
Recruiting
Address
Hopital Prive d'Antony /ID# 253501
Antony, Ile-de-France, 92160
Status
Recruiting
Address
Polyclinique Courlancy /ID# 254680
Reims, Marne, 51100
Status
Recruiting
Address
CHU de Nantes, Hotel Dieu -HME /ID# 254114
Nantes, Pays-de-la-Loire, 44000
Status
Recruiting
Address
HCL - Hopital Edouard Herriot /ID# 253500
Lyon, Rhone, 69003
Status
Recruiting
Address
Havelklinik /ID# 254194
Berlin, , 13595
Status
Recruiting
Address
Klinikum Ruhr Univ Bochum /ID# 253690
Bochum, , 44791
Status
Recruiting
Address
Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 254510
Bramsche, , 49565
Status
Recruiting
Address
Magdeburger Company for Medical Studies & Services GmbH /ID# 255151
Magdeburg, , 39104
Status
Recruiting
Address
Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 253691
Mainz, , 55128
Status
Recruiting
Address
Klinik am Biederstein /ID# 254195
Munich, , 80802
Status
Recruiting
Address
Universitaetsklinikum Regensburg /ID# 253692
Regensburg, , 93042
Status
Recruiting
Address
401 GSNA - 401 Army General Hospital /ID# 253499
Athens, Attiki, 11527
Status
Recruiting
Address
University General Hospital Attikon /ID# 253495
Athens, Attiki, 12462
Status
Recruiting
Address
General Hospital Andreas Syggros /ID# 253498
Athens, Attiki, 16121
Status
Recruiting
Address
Papageorgiou General Hospital /ID# 253496
Thessaloniki, , 56429
Status
Recruiting
Address
Debreceni Egyetem-Klinikai Kozpont /ID# 253637
Debrecen, Hajdu-Bihar, 4032
Status
Recruiting
Address
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 253913
Kaposvár, Somogy, 7400
Status
Recruiting
Address
Csalogany Orvosi Kozpont /ID# 255063
Budapest, , 1027
Status
Recruiting
Address
Obudai Egeszsegugyi Centrum Kft. /ID# 256366
Budapest, , 1036
Status
Recruiting
Address
DERMA-B Egeszsegugyi es Szolgaltato - Debrecen - Gyepusor Utca /ID# 253638
Debrecen, , 4031
Status
Recruiting
Address
Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 253753
Pecs, , 7624
Status
Recruiting
Address
Szegedi Tudományegyetem /ID# 255142
Szeged, , 6720
Status
Recruiting
Address
St James Hospital /ID# 253973
Dublin 8, Dublin, D08 NHY1
Status
Recruiting
Address
South Infirmary Victoria University Hospital /ID# 253975
Cork, , T12 X23H
Status
Recruiting
Address
University College Dublin /ID# 253971
Dublin, , D07 A8NN
Status
Recruiting
Address
University Hospital Galway /ID# 253976
Galway, , H91 YR71
Status
Recruiting
Address
Waterford Regional Hospital /ID# 254038
Waterford, , X91 ER8E
Status
Recruiting
Address
Rambam Health Care Campus /ID# 254406
Haifa, H_efa, 3109601
Status
Recruiting
Address
ZIV Medical Center /ID# 254403
Safed, HaTsafon, 13100
Status
Recruiting
Address
Sheba Medical Center /ID# 254545
Ramat Gan, Tel-Aviv, 52621
Status
Recruiting
Address
Tel Aviv Sourasky Medical Center /ID# 254404
Tel Aviv, Tel-Aviv, 6423906
Status
Recruiting
Address
Rabin Medical Center /ID# 254405
Haifa, , 4941492
Status
Recruiting
Address
Azienda Ospedaliero Universitaria di Ferrara - Ospedale Sant'Anna /ID# 254496
Cona, Ferrara, 44124
Status
Recruiting
Address
Fondazione PTV Policlinico Tor Vergata /ID# 254498
Rome, Roma, 00133
Status
Recruiting
Address
ASST Spedali civili di Brescia /ID# 254875
Brescia, , 25123
Status
Recruiting
Address
Ospedale Piero Palagi /ID# 254495
Florence, , 50122
Status
Recruiting
Address
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 254502
Milan, , 20122
Status
Recruiting
Address
Azienda Ospedaliero Universitaria Pisana /ID# 254501
Pisa, , 56126
Status
Recruiting
Address
Fondazione Policlinico Universitario Agostino Gemelli /ID# 254500
Roma, , 00168
Status
Recruiting
Address
Fukuoka University Hospital /ID# 254729
Fukuoka-shi, Fukuoka, 814-0180
Status
Recruiting
Address
Meiwa Hospital /ID# 254728
Nishinomiya-shi, Hyogo, 663-8186
Status
Recruiting
Address
University of Tsukuba Hospital /ID# 254638
Tsukuba-shi, Ibaraki, 305-8576
Status
Recruiting
Address
University Hospital Kyoto Prefectural University of Medicine /ID# 254481
Kyoto-shi, Kyoto, 602-8566
Status
Recruiting
Address
Tohoku University Hospital /ID# 254598
Sendai-shi, Miyagi, 9808574
Status
Recruiting
Address
University of the Ryukyus Hospital /ID# 254517
Nakagami-gun, Okinawa, 903-0215
Status
Recruiting
Address
Kindai University Hospital /ID# 254574
Osakasayama-shi, Osaka, 589-8511
Status
Recruiting
Address
Shiga University of Medical Science Hospital /ID# 254215
Otsu-shi, Shiga, 520-2192
Status
Recruiting
Address
Nihon University Itabashi Hospital /ID# 254637
Itabashi-ku, Tokyo, 173-8610
Status
Recruiting
Address
Toranomon Hospital /ID# 253819
Minato-ku, Tokyo, 105-8470
Status
Recruiting
Address
Korea University Ansan Hospital /ID# 254128
Ansan, Gyeonggido, 15355
Status
Recruiting
Address
CHA Bundang Medical Center /ID# 254026
Seongnam, Gyeonggido, 13496
Status
Recruiting
Address
Seoul National University Hospital /ID# 254027
Seoul, , 03080
Status
Recruiting
Address
SoonChunHyang University Seoul Hospital /ID# 254025
Seoul, , 04401
Status
Recruiting
Address
Hallym University Kangnam Sacred Heart Hospital /ID# 254127
Seoul, , 07441
Status
Recruiting
Address
Inlita Santara CTC /ID# 253917
Vilnius, , 08406
Status
Recruiting
Address
Vilnius University Hospital Santaros Klinikos /ID# 253916
Vilnius, , 08411
Status
Recruiting
Address
Amphia Ziekenhuis /ID# 253567
Breda, Noord-Brabant, 4818 CK
Status
Recruiting
Address
Universitair Medisch Centrum Groningen /ID# 253571
Groningen, , 9713 GZ
Status
Recruiting
Address
Greenlane Clinical Centre /ID# 254351
Epsom, Auckland, 1051
Status
Recruiting
Address
Clinical Trials New Zealand /ID# 254352
Hamilton, , 3204
Status
Recruiting
Address
Hospital CUF Descobertas /ID# 254323
Lisboa, , 1998-018
Status
Recruiting
Address
Centro Hospitalar de Lisboa Central /ID# 254325
Lisbon, , 1169-050
Status
Recruiting
Address
Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 254322
Porto, , 4099-001
Status
Recruiting
Address
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 254324
Porto, , 4200-319
Status
Recruiting
Address
Dr. Samuel Sanchez PSC /ID# 253948
Caguas, , 00727
Status
Recruiting
Address
Alma M. Cruz Santana, MD-Private practice /ID# 253951
Carolina, , 00985
Status
Recruiting
Address
King Faisal Specialist Hospital and Research Centre /ID# 255279
Riyadh, Ar Riyad, 11211
Status
Recruiting
Address
King Abdulaziz Medical City- National Guard Hospital /ID# 255280
Riyadh, Ar Riyad, 11426
Status
Recruiting
Address
King Faisal Specialist Hospital /ID# 255539
Jeddah, Makkah, 23433
Status
Recruiting
Address
King Saud University Med City /ID# 255282
Riyadh, , 12372
Status
Recruiting
Address
National Skin Centre /ID# 255242
Singapore, Central Singapore, 308205
Status
Recruiting
Address
National University Hospital /ID# 254943
Singapore, , 119074
Status
Recruiting
Address
Univerzitna nemocnica Martin /ID# 254153
Martin, Zilinsky Kraj, 036 01
Status
Recruiting
Address
Univerzitna nemocnica Bratislava /ID# 254157
Bratislava, , 821 01
Status
Recruiting
Address
Fakultna nemocnica Trnava /ID# 254137
Trnava, , 917 02
Status
Recruiting
Address
Hospital Universitari de Bellvitge /ID# 254982
L'Hospitalet de Llobregat, Barcelona, 08907
Status
Recruiting
Address
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 253924
Majadahonda, Madrid, 28222
Status
Recruiting
Address
Hospital de Manises /ID# 253867
Manises, Valencia, 46940
Status
Recruiting
Address
Hospital Santa Creu i Sant Pau /ID# 253869
Barcelona, , 08041
Status
Recruiting
Address
Hospital General de Granollers /ID# 253873
Barcelona, , 08042
Status
Recruiting
Address
Hospital Universitario Virgen de las Nieves /ID# 253870
Granada, , 18014
Status
Recruiting
Address
Hospital Universitario Ramon y Cajal /ID# 253871
Madrid, , 28034
Status
Recruiting
Address
Hospital Universitario y Politecnico La Fe /ID# 253868
Valencia, , 46026
Status
Recruiting
Address
Karolinska Universitetssjukhuset Solna /ID# 254808
Solna, , 171 64
Status
Recruiting
Address
Kantonsspital St. Gallen /ID# 255243
St. Gallen, Sankt Gallen, 9007
Status
Recruiting
Address
Inselspital, Universitaetsspital Bern /ID# 254736
Bern, , 3010
Status
Recruiting
Address
University Hospital Zurich /ID# 254642
Zürich, , 8091
Status
Recruiting
Address
Kaohsiung Chang Gung Memorial Hospital /ID# 254031
Kaohsiung City, Kaohsiung, 833
Status
Recruiting
Address
Changhua Christian Hospital /ID# 254032
Changhua City, Changhua County, , 50006
Status
Recruiting
Address
National Taiwan University Hospital /ID# 254030
Taipei City, , 100
Status
Recruiting
Address
Linkou Chang Gung Memorial Hospital /ID# 254033
Taoyuan City, , 333
Status
Recruiting
Address
Uludag University Medical Faculty /ID# 253806
Bursa, , 16059
Status
Recruiting
Address
Ondokuz Mayis Universitesi Tip /ID# 254034
Samsun, , 55139
Status
Recruiting
Address
University Hospital Southampton NHS Foundation Trust /ID# 254531
Southampton, Hampshire, SO16 6YD
Status
Recruiting
Address
Leeds Teaching Hospitals NHS Trust /ID# 254616
Leeds, , LS9 7TF
Status
Recruiting
Address
Chelsea and Westminster Hospital NHS Foundation Trust /ID# 254190
London, , SW10 9NH
Status
Recruiting
Address
Northern Care Alliance NHS Group /ID# 256910
Salford, , M6 8HD
Status
Recruiting
Address
St George's University Hospitals NHS Foundation Trust /ID# 256803
Tooting, , SW17 0QT